Get emergency medical help if you have any signs of an allergic reaction to doxycycline: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Doxycycline causing intense flushing I am having intense flushing since basically the first time I used it. I did not have such flushing before the doxy, but am unsure if the doxy may not be a culprit and could be a red herring. Doxycycline Hyclate Hi, I'm 16 years old and I've had a problem with a red face the past couple years. It was on and off, though. First of all, it only comes during the winter. Doxycycline makes skin so sensitive to sunlight that even a little exposure can cause a sun rash with red spots, weird discoloration and even sores. I though that I would be fine as long as I had sunblock on but that is not the case. Learn about the potential side effects of doxycycline. Includes common and rare side effects information for consumers and healthcare professionals. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, fever or chills, cough, sore throat, swollen, painful, or tender lymph glands in the neck, armpit, or groin, or yellow skin or eyes while using this medicine. Downside To Doxycycline Treatment For Acne. The antibiotic doxycycline is considered to be a kinder, gentler alternative to minocycline, an antibiotic more often used to treat acne in the United States. Summary. Red face is found among people who take Doxycycline hyclate, especially for people who are male, 60+ old , have been taking the drug for 1 month, also take medication Lisinopril, and have Multiple sclerosis. ieflushing, pustules,red veins, red face. My rosacea had pretty much been in remission for quite a long time until I reached menopause and then I got the flushing. numbness or tingling of the face, hands, or feet pain in the stomach, side, or abdomen, possibly radiating to the back red skin lesions, often with a purple center.