Depakote/Divalproex Sodium Oral Tab DR: 125mg, 250mg, 500mg DOSAGE & INDICATIONS For the monotherapy or adjunct treatment of simple absence seizures, complex absence seizures, or complex partial seizures, and adjunctively for other seizure types that include absence or partial complex seizures (e.g., tonic-clonic seizures, myoclonic seizures). Valproic Acid t. The time to C max (t max) and C min (t min) values determined following administration of divalproex or divalproex ER are summarised in Table II. Depakote Sprinkle Capsules are also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types that include absence seizures. Epilepsy. Depakote Sprinkle Capsules are administered orally. As Depakote dosage is titrated upward, concentrations of clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, phenobarbital, carbamazepine, and/or phenytoin may be affected [see Drug Interactions ]. Complex Partial Seizures Divalproex Extended Release (ER) versus Divalproex Bioavailability Assessments. The bioavailability of divalproex ER relative to divalproex has been evaluated in five multiple-dose studies. Conversion from Depakote to Depakote ER In adult patients and pediatric patients 10 years of age or older with epilepsy previously receiving Depakote, Depakote ER should be administered once-daily using a dose 8 to 20% higher than the total daily dose of Depakote (Table 1). Learn about the three Depakote® (divalproex sodium) dose forms for epilepsy: tablets, ER tablets, & Sprinkles. Which Depakote is right for your patient. Divalproex sodium occurs as a white powder with a characteristic odor. Depakote Sprinkle Capsules are for oral administration. Depakote Sprinkle Capsules contain specially coated particles of divalproex sodium equivalent to 125 mg of valproic acid in a hard gelatin capsule. oral tablets, 2008; Prod Info DEPAKOTE(R) sprinkle oral capsules, 2008; Prod Info DEPAKOTE(R) oral tablets, 2006) c) conversion to monotherapy, initial, 10 to 15 mg/kg/day ORALLY, may increase dosage 5 to 10 m Medscape - Seizures, mania, and migraine prophylaxis dosing for Depakote (divalproex sodium), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.