I had problems with acid reflux before I got pregnant so you can imagine how bad it is right now! I have been taking a Zantac every night before bed since I cannot take Prevacid anymore (not for sure on this but I imagine it is a category c which I am trying to stay away from). Keep MOTILIUM tablets in the pack until it is time to take them. Keep MOTILIUM tablets in a cool dry place where the temperature is below 30°C. Keep your medicines where children cannot reach them. It is recommended that Motilium tablets are taken before meals, because they can take longer to work if they are taken after meals. Do not take more than three tablets in any 24 hour period. Hi everyone,im on my 3rd pregnancy and was so sick the 1st 2 times im determined to find a better way to cope this time. Unforntunatly i cant take buccastem or any drugs from that group as they have a nasty effect on my muscles. Motilium should be used at the lowest effective dose for the shortest duration necessary to control nausea and vomiting. It is recommended to take oral Motilium before meals. Doctors give unbiased, trusted information on whether Domperidone can cause or treat Pregnancy: Dr. Munshower on is it safe to take domperidone during pregnancy: Domperidone is rated pregnancy category c. That is, animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in. Animal studies at up to 40 mg/kg/day have revealed no fetal harm; studies at 40 mg/kg/day (21 times the human dose) showed marked impairment of fertility in one animal model. Many mothers take Motilium between 3 and 8 weeks. However, sometimes it’s needed for longer. In fact, some mothers have found they need to take it until weaning to maintain their milk supply. People taking Motilium for gastric problems have often been taking it for many years. If you take domperidone after a meal, it will still work, but it may take longer to have an effect. Domperidone should be taken for a short period of time only. Your treatment will last no longer than seven days. Doctors give unbiased, trusted information on whether Motilium can cause or treat Pregnancy: Dr. Minich on is it safe to use motilium during pregnancy: Motilium is not commercially available in the usa. Animal studies did not produce birth defects but human tests are lacking. It does pass into breast milk but it's unknown whether it causes.