-Patients should be advised to follow package directions for over the counter acetaminophen products including observing the maximum single dose and maximum daily dose limits. -Patients should be discouraged from using multiple acetaminophen containing products concurrently. Tylenol, whose active ingredient is acetaminophen, will now have a lower recommended daily dose, which is aimed at reducing the risk of accidental overdose, McNeil Consumer Healthcare, a. TYLENOL® Dosage for Adults It is important to note that maximum daily doses and labeling instructions differ between Canada and the United States. The information provided below is applicable to product sold in Canada only. Historically, the maximum daily adult dose of acetaminophen is 4 g, with a recommended dosage of 352-650 mg every 4-6 hours or 1 g every 6 hours. Detailed dosage guidelines and administration information for Tylenol Arthritis Pain (acetaminophen). Includes dose adjustments, warnings and precautions. July 28, 2011 -- The maximum dose of Extra Strength Tylenol brand acetaminophen will soon be six, not eight pills a day. Johnson & Johnson's McNeil Consumer Healthcare announced the voluntary. To help encourage the safe use of acetaminophen, the makers of TYLENOL® have lowered the maximum daily dose for single-ingredient Extra Strength TYLENOL® (acetaminophen) products sold in the U.S. from 8 pills per day (4,000 mg) to 6 pills per day (3,000 mg). The dosing interval has also changed from 2 pills every 4 – 6 hours to 2 pills every 6 hours. The maximum dose is 4 g (4000 mg); this would be equivalent to 8 extra strength tablets. Although long term use at this dose is common in the UK, it can cause serious liver damage over decades of use. Dosage de TYLENOL® chez les adultes Il est important de noter que la dose quotidienne maximale et les directives fournies sur l’emballage d’un produit diffèrent entre le Canada et les États-Unis. Acetaminophen is an active ingredient in hundreds of over-the-counter (OTC) and prescription medicines. It relieves pain and fever. And, it is also combined with other active ingredients in.