SIDE EFFECTS. DIFLUCAN is generally well tolerated. In some patients, particularly those with serious underlying diseases such as AIDS and cancer, changes in renal and hematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and. Along with its needed effects, fluconazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Side Effects. Nausea, vomiting, diarrhea, stomach upset/pain, headache, dizziness, or hair loss may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Along with its needed effects, fluconazole (the active ingredient contained in Diflucan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. It will give you more information about fluconazole and will provide you with a full list of the side-effects which you may experience from taking it. There are several strengths of fluconazole capsule available - 50 mg, 150 mg, and 200 mg. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. I was recently prescribed Diflucan to treat a YI.it did wonders to resolve the YI after a day or so, but I have noticed some odd side effects: vaginal dryness, facial skin dryness and facial acne breakouts. View detailed reports from patients taking diflucan who experienced dry skin. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Vulvovaginal dryness is found among people who take Diflucan, especially for people who are 40-49 old also take medication Synthroid, and have Breast cancer metastatic. This study is created by eHealthMe based on reports of 22,370 people who have side effects when taking Diflucan from FDA, and is updated regularly.