If you take 4 mg for only a day, you should not have trouble stepping down to 2 mg. But you need to do this with the guidance of a good doctor who understands Lorazepam and Benzodiazepine drugs. Uses: Lorazepam is prescribed for Anxiety and Panic Attacks and is mostly mentioned together with these indications. In addition, our data suggest that some patients take it for Withdrawal Symptoms and Insomnia, although this is not an approved use*. says take 1 Lorazepam 1 MG ever 6 houes.The TEMAZAPAM SAYS TAKE 1 AT BEDTIME AS NEED ED FOR SLEEP. Took them 4 hours ago and I am awake again. It has only been 4 hours, Can I go ahead and Took them 4 hours ago and I am awake again. You can, but. You may have a lot of trouble waking up in the morning. I assume you would take nyquil at night like it is intended, and often Lorazepam is taken at night for sleep. It didn't help me to sleep all night as I woke around 3:30, no matter how late I stayed up. Then I was put on Mirtazapine (15 mg) at night. Dr. said if I still woke up at that early hour to take 1/2 Lorazapem. Is this combination safe. Mixing sedating medications can be difficult because they can have more than additive effects. Be careful. Be careful. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Fowler on lorazepam and nyquil: Xanax (alprazolam) and nyquil are sedating. But you can take both together, however, it can result in a longer duration of sleep as well as a slight hang over after waking up, no drug interactions have been reported when Benzodiazepines such as Ativan are taken with Ambein though. Chronic use of benzodiazepine (a class of medications that include lorazepam) can alter your memory and mood, your immune system. They also increase the risk of depression, anxiety disorders, and a variety of mental illnesses. Ticktick, I wouldn't suggest taking either unless your doctor prescribes you one or the other. I certainly wouldn't take both because they are both benzos and can become highly addictive. If you take lorazepam for longer than four weeks your body can become tolerant to its effects, which means you would need increasing doses to achieve the same effect. You can also become dependent.