Topical Corticosteroids. Tier-1 products are covered with no prior authorization necessary. Tier-2 Topical Corticosteroid Approval Criteria: Documented trials of all Tier-1 topical corticosteroids of similar potency in the past 30 days that did not yield adequate relief; AND How to use Clotrimazole-Betamethasone Lotion. Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. Deciphers the medication betamethasone dipropionate (Diprolene, Diprolene AF, Diprosone, Alphatrex), a drug used for for the relief of itching and inflammation associated with a wide variety of skin conditions. Betamethasone cream is a medicine used to treat skin infections. Typical skin infections treated by creams containing this medication include athlete's foot, jock itch, and ringworm. How to use Betamethasone Dipropionate Cream. Use this medication on the skin only. However, do not use it on the face, groin, or underarms or for diaper rash unless directed to do so by your doctor. Betamethasone dipropionate is a white to creamy-white, odorless crystalline powder, insoluble in water. Each gram of LOTRISONE cream contains 10 mg clotrimazole and 0.643 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a white to off-white, hydrophilic cream consisting of benzyl alcohol as a preservative, ceteareth-30. Betamethasone is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. Betamethasone dipropionate, USP is a white to creamy-white, odorless crystalline powder, insoluble in water. Each gram of clotrimazole and betamethasone dipropionate cream, USP contains 10 mg clotrimazole, USP and 0.64 mg betamethasone dipropionate, USP (equivalent to 0.5 mg betamethasone), in a white to off-white hydrophilic cream. BETAMETHASONE is a corticosteroid. It is used on the skin to treat itching, redness, and swelling caused by some skin conditions. The lowest GoodRx price for the most common version of betamethasone valerate is around $19.96, 60% off the average retail price of $51.14. Betamethasone is a steroid that prevents the release of substances in the body that cause inflammation. Betamethasone topical (for the skin) is used to treat the inflammation and itching caused by a number of skin conditions such as eczema or psoriasis.