2 Approved Revised , , INTRODUCTION The antiplatelet agents, including aspirin, clopidogrel prasugrel, ticagrelor, ticlopidine, and others have a Plavix (clopidogrel bisulfate) and Eliquis (apixaban) are anticoagulants (blood thinners) that inhibit aspects of blood clotting and are used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Aspirin should be taken with food. Doses range from 50 mg to 6000 mg daily depending on the use. Usual doses for mild to moderate pain are 350 or 650 mg every 4 hours or 500 mg every 6 hours. Learn about Plavix (Clopidogrel Bisulfate) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Coumadin and Plavix are both anti-platelet agents as well as aspirin. The most widely studied and prescribed antiplatelet agent for the prevention of stroke and other serious vascular events among high vascular risk patients is aspirin. Questions about dosage and length of treatment with Plavix (clopidogrel), Effient (prasugrel), and aspirin after having a stent? Have you experienced allergic reactions or side-effects? Join the conversation. My cardiologists suggested I read about the DAPT trials in regards to Plavix-aspirin therapy and the length of therapy. I had 2 des, which are first generation, 15 months ago. CAPRIE (Plavix vs Aspirin) In CAPRIE, gastrointestinal hemorrhage occurred at a rate of 2.0% in those taking Plavix versus 2.7% in those taking aspirin; bleeding requiring hospitalization occurred in 0.7% and 1.1%, respectively. Brilinta (ticagrelor) and Plavix (clopidogrel) are two antiplatelet medications that can be used to prevent clots from forming in the blood. Both medications are indicated to reduce the risk of heart and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction (MI or heart attack). So he should either stay on Plavix or switch completely to Aspirin. Plavix is more potent but also has more side effects than aspirin (bruizing, gastrointestinal bleeding, stomach ulcers, etc).