Zofran can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment. Find patient medical information for Zofran oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ZOFRAN does not alter the respiratory depressant effects produced by alfentanil or the degree of neuromuscular blockade produced by atracurium. Interactions with general or local anesthetics have not been studied. Drug Abuse And Dependence. Animal studies have shown that ondansetron is not discriminated as a benzodiazepine nor does it substitute for benzodiazepines in direct addiction studies. Ondansetron (Zofran) is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy. It is also used to prevent or treat nausea and vomiting after surgery. This drug is more popular than comparable drugs. It is available in brand and generic form. It is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. Ondansetron comes as a tablet, a rapidly disintegrating (dissolving) tablet, film, and an oral solution (liquid) to take by mouth. The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Zofran ODT tablets are a freeze‑dried, orally administered formulation of ondansetron which disintegrates on the tongue and does not require water to aid dissolution or swallowing. Each 5 mL of Zofran oral solution contains 5 mg of ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron. Zofran oral solution contains the. Ondansetron, commonly known by the brand name Zofran®, is used in dogs and cats to treat a variety of conditions with the most common being vomiting. It can also be used to treat sleep-apnea and pruritus (itching) in some pets. Ondansetron is a drug that selectively inhibits serotonin 5HT3 receptors. 5HT3 receptors are located on vagal nerve terminals, enteric neurons in the GI tract, and. Ondansetron (Zofran®) August 1, 2020. This sheet talks about exposure to ­­­­­ondansetron in a pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider. What is ondansetron? Ondansetron is a medication used to treat nausea and vomiting that may be caused by surgery, chemotherapy, or radiation therapy. Find everything you need to know about ondansetron (Zofran), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about ondansetron (Zofran) at. ZOFRAN ODT orally disintegrating tablets are white, round, and plano-convex tablets available in the following strengths: 4 mg - debossed with “Z4” on one side. 8 mg - debossed with “Z8” on one side. ZOFRAN oral solution, 4 mg/5 mL, is a clear, colorless to light yellow liquid with a characteristic strawberry odor available in a 50-mL bottle. Storage And Handling ZOFRAN Tablets. 4 mg.