This is as true with Xanax® XR as with standard alprazolam medication. Even with the smallest amount of medication and a small drink, the side effects of Xanax® are magnified and can result in a great deal of emotional and physical turmoil. Effects Associated with Mixing Alcohol and Xanax When taken within its therapeutic dosage range, Xanax is generally considered to be safe. When individuals take small doses of both Xanax and alcohol, the potential for severe interactions is minimized compared to the potential effects that could occur with higher doses. It is generally recommended that you avoid drinking alcohol during treatment with Xanax. Alcohol can not only increase your risk of certain Xanax side effects, but it may also worsen mental illness in people with anxiety or panic disorder. Xanax and Alcohol – Not to be Mixed Published on September 14th, 2016 Combining Xanax and Alcohol is among the most harmful drug combinations for the body and brain. Xanax is a prescription anti-anxiety medication marketed by Pfizer Inc. also sold in generic form under its chemical name, alprazolam. Classified as a benzodiazepine central nervous system depressant, Xanax comes with a warning label against drinking alcohol while taking it. Hi, everybody is different, and although some people can mix alcohol with Xanax & experience little to no side effects, overall this combination should be avoided. Xanax (alprazolam) is a benzodiazepine medication used to treat anxiety and panic disorders. Includes side effects, interactions and safety information. Includes side effects, interactions and safety information. Mixing alcohol with Xanax can be deadly. The substances can cause devastating side effects that make you pass out, black out and stop breathing. Taking Xanax with other drugs or alcohol can be a deadly mistake. According to the American Journal of Forensic Medicine and Pathology, fatalities from taking Xanax, or alprazolam, on its own are rare. When combined, Xanax and alcohol can cause various side effects, some of which can be fatal. This is why alcohol and Xanax should never be combined. Even if you think you’re responsible with your drinking, and Xanax is taken as prescribed, it’s important to still be aware of the dangers of taking Xanax with alcohol.