This is tricky and iffy, so I will just say this. I have a drawer of old meds that I have kept along the route, If I have needed a muscle relaxer or a pain reliever that I have had prescribed to be before and it has an expired date, I've taken it and its been fine. This is what I would do and does not mean that it is right or wrong. Liquid Oral Medications Most liquid medications that are not reconstituted also have a shelf life of 1 to 2 years but once reconstituted (mixed with water – such as powered amoxicillin is mixed with water) – most expire in about 7 to 14 days depending on the specific product. For 2 days now I have been suffering from an extremely painful toothache while waiting for antibiotics to take control of the infection. I am taking Tramadol that expired 2 years ago to control my pain. By: Kara McCarty El Segundo, CA Replied on . The shelf life of Tramadol is 36 months after its formulation, as long as it is stored in a cool, dark environment. She actually has tramadol left from her surgery in Feb. 2011 and there's no expiration date. She also has Glucosamine tablets we purchased from the vet. As far as the expired side effects of Tramadol go this is not likely to be a serious problem or dangerous for your dog. All that happens is that the drug becomes slightly less effective and this effect increases the more out of date the drug becomes. Rimadyl and other dog medications are pharmaceutical preparations which fall under the auspices of the Food and Drug Administration. As active ingredients are unstable over time, dog medications have an expiration date just like human medicines. does tramadol hcl have an expiration date - WebMD …The chances are heavily in favor that your tramadol pills (labeled with a 12/21/10 discard date) are still effective. The Tramadol should have an expiry date on the box, usually found on the back. I want to make it clear that the expiry date doesn't always mean the medication is no longer safe or useful. WARNINGS: Tramadol has a risk for abuse and addiction, which can lead to overdose and death. Tramadol may also cause severe, possibly fatal, breathing problems.