The maximum dose will vary by patient age and by what you are usingthe drug to treat, but the maximum recommended beginning dose foran adult is 20 mg per day. * If it turns out your liver disease is minimal - the adult maximum dose of acetaminophen is 4 grams per day (4000 milligrams). If you take more than the maximum daily amount, it may cause serious (possibly fatal) liver disease. Maximum dose: 6 doses/day not to exceed 90 mL/24 hours Hydrocodone 10 mg-acetaminophen 300 mg per 15 mL: Initial dose: 11.25 mL every 4 to 6 hours as needed for pain However, the dose is usually not more than 33.6 mL (6 and 1/2 teaspoonfuls) per day. Children 4 to 6 years of age and weighing 16 to 22 kg—3.75 mL (3/4 teaspoonful) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. The maximum you can take per day is somwhat dependent on the amount of acetominophen. You can take up to 1000mg at a time, no more than 4000mg a day of acetominophen. You can take up to 1000mg at a time, no more than 4000mg a day of acetominophen. Postoperatively, the neurosurgeon prescribes tablets containing hydrocodone bitartrate 10 mg and acetaminophen 325 mg at a dosage of two tablets four times a day, with a maximum daily dose of eight tablets. The dispensing pharmacist might question the appropriateness of this prescription because some sources list the maximum daily hydrocodone bitartrate dose as 60 mg. In this example, the. What is the maximum dosage of hydrocodone (5/325) in a day can one take without overdosing. Already up to 90 mgs, what is lethal. I am still in pain and am afraid to take more. Already up to 90 mgs, what is lethal.