Always tell your doctor about any legal and illegal drugs, supplements, and herbal remedies you are taking. Spironolactone can have a negative interaction with the following drugs: What should I discuss with my healthcare provider before taking spironolactone (Aldactone, CaroSpir)? You should not use spironolactone if you are allergic to it, or if you have: Aldactone may be taken with or without food. The dosage range is 25-400 mg daily in single or divided doses. The initial dose for treating edema in adults is 100 mg daily as a single dose or divided doses. What is doxycycline. If Clostridium difficile associated diarrhea suspected or confirmed, may doxycycline delivered overnight need to what discontinue ongoing antibacterial use doxycycline not directed against. What other drugs will affect Aldactone? Taking this medicine with other drugs that make you dizzy or lower your blood pressure can worsen these effects. WARNING. ALDACTONE has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS). ALDACTONE should be used only in those conditions described under Indications and Usage. Initially, 12.5 to 25 mg PO once daily. May reduce dosage to 25 mg PO every other day if hyperkalemia occurs with 25 mg PO once daily. May increase dosage to 50 mg/day, if clinically indicated and lower dose tolerated. Food and drinks don’t mix with certain drugs. They can cause delayed, decreased or enhanced absorption of a medication. MAO inhibitors and blood pressure: Eating chocolate and peanut butter can be a tasty combination, but eating chocolate and taking certain drugs could carry risks. High-potassium fruits you should avoid when taking Aldactone include papaya, cantaloupe, prune juice, honeydew melons, bananas, raisins, mangoes, kiwis, oranges and orange juice. Because of the risk of hyperkalemia, your physician may require you to follow certain dietary restrictions when taking Toprol-XL. You may be advised to avoid foods high in potassium, so it will be important to make yourself aware of these foods.