I am actually on my last day of weaning myself off of 60 mg per day of cymbalta. I just moved to a new city so I did it without a doctor (which by almost everyone's account is NOT recommended). Weaning Off Cymbalta: Enough is enough! Whether you are deciding to take less meds or your Dr. prescribed to you to start weaning off them. Find help from others in here. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Hey jenn, It will be difficult to wean off the Prozac (fluoxetine) by halving the pills as it is a capsule if you are on a dose higher than 10mgs. In 2008, Cymbalta became the second drug to receive FDA approval for the treatment of fibromyalgia. It was classified as a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant. Cymbalta is the brand name for the drug duloxetine. It belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs work by changing the balance of the chemical. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Riney on tapering off trazodone: 50 mgm trazadone, 48 hours later you still have the effects. You probably went to see an md with some complaints, which included sleep disturbance.He gave you trazadone and you sort of sleeping since then. Time for total truth. What. Cymbalta (Duloxetine) is used to treat depression. The drug is in a class of antidepressants called serotonin-norepinephrine reuptake inhibitors (SNRIs). Weaning off antidepressants, including Lexapro, Zoloft, Paxil, and others, can come with some side effects. We’ll talk about when to talk with your doctor and how to taper these medications safely. ARE YOU NEW HERE? Words from the wise about Cymbalta: The following items are based on the experiences of people posting on this board.