Vytorin (ezetimibe and simvastatin) lowers bad cholesterol in the blood, and raises good cholesterol. Including Vytorin side effects, interactions and indications. Ezetimibe/simvastatin is a drug combination used for the treatment of dyslipidemia. It is a combination of ezetimibe (known as Zetia in the United States) and the statin drug simvastatin (known as Zocor in the U.S.). Vytorin is a combination of ezetimibe and simvastatin that is used for treating high levels of cholesterol in the blood. Vytorin reduces total cholesterol and low density lipoprotein (LDL or bad ) cholesterol while it increases high density lipoprotein (HDL or good ) cholesterol. VYTORIN® (ezetimibe and simvastatin) Tablets. DESCRIPTION. VYTORIN contains ezetimibe, a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and simvastatin, an HMG-CoA reductase inhibitor. Whenever you pick up a prescription medication, you may notice little stickers on the bottle that say “Take on an empty stomach” or “Take with food.” Vytorin (ezetimibe and simvastatin) is a combination of a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and an HMG-CoA reductase inhibitor (also called a statin ) used to treat high blood cholesterol. Ezetimibe/simvastatin (Vytorin) is an expensive drug used to lower cholesterol. This drug is more popular than comparable drugs. It is available in generic and brand versions. Ezetimibe is used together with lifestyle changes (diet, weight-loss, exercise) to reduce the amount of cholesterol (a fat-like substance) and other fatty substances in the blood. This is a randomized, active-control, double-blind study of subjects with stabilized high-risk acute coronary syndrome (ACS). The primary objective is to evaluate the clinical benefit of Ezetimibe/Simvastatin Combination 10/40 (single tablet, under the brand VYTORIN in the United States) compared with Simvastatin 40 mg. Vytorin is available for oral use as tablets containing 10 mg of ezetimibe, and 10 mg of simvastatin (Vytorin 10/10), 20 mg of simvastatin (Vytorin 10/20), 40 mg of simvastatin (Vytorin 10/40), or 80 mg of simvastatin (Vytorin 10/80).