Other common side effects are gas, constipation, dry mouth, nausea, hand or foot swelling and a fast heartbeat. If these symptoms bother you or do not go away within several days on the medication, call your doctor. Tell your doctor if you have serious side effects of Vicodin including shallow breathing, slow heartbeat, fainting, confusion, fear, unusual thoughts or behavior, seizures (convulsions), upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or yellowing of the skin or eyes. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. If you notice any other effects, check with your healthcare professional. Along with its needed effects, hydrocodone/ibuprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. Find information about common, infrequent and rare side effects of Vicodin Oral. Vicodin Vicodin and Leg Swelling; Experiences Side Effects & Concerns Compare Medications Drug Facts. Vicodin and Leg Swelling. 17 discussions around the web mention both. About Vicodin. 2.8? 306,363 Discussions. Vicodin is a pain relief medication. Uses: Vicodin is prescribed for Pain and is mostly mentioned together with this indication. Read More. See more about. Vicodin Leg Swelling. There is no Foot, leg, and ankle swelling reported by people who take Vicodin yet. This review analyzes which people have Foot, leg, and ankle swelling with Vicodin. It is created by eHealthMe based on reports from FDA, and is updated regularly. Summary. There is no Leg swelling reported by people who take Vicodin yet. This review analyzes which people have Leg swelling with Vicodin. It is created by eHealthMe based on reports from FDA, and is updated regularly. Note: This document contains side effect information about acetaminophen / hydrocodone. Some of the dosage forms listed on this page may not apply to the brand name Vicodin.