Advil and Tylenol are both medications used to relieve pain and reduce fevers. Advil also has anti-inflammatory properties, so it is used for treating arthritis or joint pain. It’s good to know however that TYLENOL® will not irritate the stomach the way naproxen sodium (Aleve®), or even Ibuprofen (Advil®, MOTRIN®) can. TYLENOL® can help relieve your pain while being gentle on your stomach. I had some pretty severe abdominal pain, but within two hours of getting home and taking Ibuprofen and Tylenol, that pain was gone and I slept all night comfortably with never any more pain. My dd has had regular abdominal pain since the day she was born. She is always gassy - something she still finds funny, but it won't be as she grows older. Is Tylenol (Acetaminophen) Bad for Your Stomach? Dr. Sharon Orrange Dr. Orrange is an Associate Professor of Clinical Medicine in the Division of Geriatric, Hospitalist and General Internal Medicine at the Keck School of Medicine of USC. home / chronic pain health center / chronic pain a-z list / acetaminophen vs ibuprofen side effects article Acetaminophen (Tylenol) vs. Ibuprofen (Advil) for Pain (Differences in Side Effects and Dosage). Doctors give unbiased, trusted information on whether Acetaminophen can cause or treat Pain: Dr. Den on advil or tylenol for tooth pain: You should not take these. Advil and Tylenol are each at their best when taken for certain ailments, in part because they work differently in the body and can have different side effects. TYLENOL® Arthritis Pain works with your body to be tough on pain and gentle on the stomach. 1st Line Therapy The medicine found in TYLENOL® Arthritis Pain caplets, acetaminophen, is recommended as first-line therapy for arthritis pain by The Canadian Rheumatology Association (CRA). Upon Tylenol use, if you have any of the following symptoms of liver damage such as severe nausea, yellowing eyes or skin, dark urine, stomach pain, extreme fatigue OR serious allergic such as rash, itching, swelling, severe dizziness, and trouble breathing seek immediate medical attention.