Compare Trazodone vs Zoloft head-to-head for uses, ratings, cost, side effects, interactions and more. Trazodone rated 6.9/10 vs Zoloft rated 7.4/10 in overall patient satisfaction. Interactions. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Review fiAntidepressant drug interactions 22 rogress in eurology and sychiatry ayune 216 drugs metabolised through this enzyme.5 This varying While there are no specific drug-drug interactions between trazodone and zoloft (sertraline), their proposed activity is similar. It is not unusual for patients to be on both, however. Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. sertraline oral and trazodone oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock. Patient Drug Interactions Source: RxList Trazodone is an oral drug, which is available as a regular-release or extended-release tablet. The tablets have a score line, or indentation down the middle. Does Zoloft Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in. Significant Drug Interactions Here are some of the drugs that can lead to significant drug interaction. Blood Thinner or Anticoagulant – When taken together with trazodone, warfarin can result in either an increase or decrease in the prothrombin time. Summary. Drug interactions are reported among people who take Trazodone hydrochloride and Zoloft together. This study is created by eHealthMe based on reports of 448 people who take Trazodone hydrochloride and Zoloft from FDA, and is updated regularly.