Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Commonly reported side effects of trazodone include: blurred vision, dizziness, drowsiness, headache, nausea, vomiting, and xerostomia. Other side effects include: syncope, edema, ataxia, confusion, diarrhea, hypotension, insomnia, sedated state, and tachycardia. Find information about common, infrequent and rare side effects of Trazodone Oral. Trazodone is a generally safe medication, but it has several potential side effects that can be dangerous. (Image: Sarawut Doungwana / EyeEm/EyeEm/GettyImages) Trazodone is approved by the Food and Drug Administration ( FDA) for use in major depressive disorder. Two of the most common side effects of trazodone are sleepiness and dizziness, but there are also black box warnings about potentially severe side effects that come with the use of this drug, such as serotonin syndrome or thoughts of suicide. Trazodone use for long periods of time increases the short-term risks (warnings) and raises the potential for further long-term side effects & withdrawal. Side Effects. See also the Warning section. Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache. The side effects your experiencing should wear off in a week or two. You need to take Trazodone then lie straight down and relax. If you don't it can have the opposite effect. Trazodone, an antidepressant sometimes used in treating bipolar disorder, is often prescribed to treat insomnia because its most frequent side effect is sedation. Trazodone's original brand name is Desyrel, and there is an extended-release form sold under the brand name Oleptro. Our Desyrel (trazodone hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur.