In one study of 101 pre- and postmenopausal women, flutamide alone or in combination with an oral contraceptive produced a marked decrease in hair loss scores after 1 year of treatment, with maximum effect after 2 years of treatment and benefits maintained for another 2 years. Fluridil is old news. If you do a search , there are threads about it on hair loss sites going all the way back to 2003. If it was any good, I'm pretty sure it wouldn't just fade into obscurity like it has. In the early 1990s, scientists in France synthesized a new topical anti-androgen called RU58841 (or RU-58841). This product was effective at tackling various androgen related disorders, including hair loss, acne and hirsutism. Well I got my topical Flutamide from Genhair today and man the stuff smells pretty powerful. I don’t know if it’s the green tea or Flutamide or Finasteride or what but it will definitely set off the olfactory senses. Well some users claim its stopped their hairloss and thickened it up a bit but no regrowth. I know for a fact they work internally so its possible to work topically depending on the success of the systematic absorbtion of these products through the scalp. Two other anti-androgens, fluridil and flutamide, are also fairly popular in the hair loss world. Due to their similar names, many people confuse the two, so I am writing one post to cover both products. I also do not want to write too many separate posts on anti-androgens, but do want to cover the main ones. Prospective Cohort Study on the Effects and Tolerability of Flutamide in Patients with Female Pattern Hair Loss Systemic flutamide treatment of female pattern hair loss Flutamide is a non-steroidal antiandrogen that is devoid of other hormonal activity. It most likely acts after converting to 2-hydroxyflutamide, which is a potent competitive inhibitor of dihydrotestosterone (DHT) binding to the androgen receptor. Topical flutamide has been used earlier for treatment of hair-loss. However, no previous study was identified to investigate topical flutamide in treating melasma. The aim of this study was to investigate efficacy of 1% flutamide cream versus 4% hydroquinone cream on melasma. Oh yes, Topical Flutamide does work. I used it but went a bit mad with doseage and had a few side effects. I not only had a total STOPPAGE in hairloss but I also had incrediable thickness plus some regrowth.