Best Answer: Talwin is an effective opiate pain reliever comparable to codiene and hydrocodone. It is a partial antagonist, meaning it causes less euphoria, and in opiate addicted patients, can cause withdrawal symptoms. Compare Talwin NX vs. Vicodin, which is better for uses like: Pain and Severe Pain. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Compare Hydrocodone vs. Talwin NX, which is better for uses like: Pain and Severe Pain. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. I agree with buddy1971. This medication causes more trauma than your pain. It doesnt treat pain it only reacts on the opiate receptors, the only reason (your pain) to take this med is blocked; causing decreased BP & HR and will make them confused, dizzy, suddenly lightheaded and faint, but not before they throw up. All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. Summary. We compare the side effects and drug effectiveness of Dilaudid and Talwin. The study is created by eHealthMe based on reports of 68,316 people who take Dilaudid and Talwin, and is updated regularly. Talwin Nx is a medication prescribed for relieving moderate-to-severe pain. This combination medication contains two active ingredients, one that is a pain reliever and another that helps prevent the drug from being abused. Tramadol and hydrocodone are two types of potent pain relievers called opioid analgesics. They’re often used to treat moderate to severe pain, such as long-term pain related to cancer or other. Compare Hydrocodone vs Talwin head-to-head for uses, ratings, cost, side effects, interactions and more. Hydrocodone rated 5.9/10 vs Talwin rated 5.7/10 in overall patient satisfaction. hydrocodone-acetaminophen oral and pentazocine-naloxone oral. hydrocodone-acetaminophen oral , pentazocine-naloxone oral. Either increases toxicity of the other by pharmacodynamic synergism.