Someone taking morphine likely feels mellow and relaxed as well as pain-free. Over time, the brain gets used to feeling this way, and some of the pathways in the brain are physically altered. This means that the brain may rely on morphine to feel happy, making a person want to take more of the drug, bypassing the natural reward pathway and creating a new shortcut pathway to feeling good. It. Taking certain medications during your treatment with morphine injection may increase the risk that you will experience serious or life-threatening breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: benzodiazepines such as alprazolam (Xanax), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), and. You should talk to your healthcare provider before taking hydromorphone or morphine if you have breathing problems such as chronic obstructive pulmonary disease (COPD) or asthma. These drugs have.