Using Alprazolam (xanax)together with Zolpidem(ambien) may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience some impairment in thinking and judgment. Benzodiazepine (BZD) toxicity may result from overdose or from abuse. Since their introduction in 1960, BZDs have come to be widely used for a variety of indications, including seizures, anxiety, alcohol withdrawal, insomnia, drug-associated agitation, and muscle spasm. HYDROXYZINE is an antihistamine. This medicine is used to treat allergy symptoms. It is also used to treat anxiety and tension. This medicine can be used with other medicines to induce sleep before surgery. Chronic pain is pain that lasts for a long time. Opioids, such as methadone and Suboxone, are strong medications prescribed to help relieve chronic pain. Oxycodone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. Lauren, the same thing happened to me! It almost felt like my liver wouldnt process the benzo suddenly (alprazolam) and I was in crazy withdrawal while taking the drug. I'm currently taking 3mg of Xanax daily for my anxiety disorder, and have an opiate addiction to OxyContin. My doctor wants to give me Suboxone to get off the OxyContin and I've heard that taking Xanax and Suboxone together was dangerous and could have adverse side effects. Expert Care. Research shows people with Parkinson’s who seek skilled care are at a lower risk of complications and have better quality of life. More than 30 percent of overdoses involving opioids also involve benzodiazepines, a type of prescription sedative commonly prescribed for anxiety or to help with insomnia. Alprazolam, sold under the trade name Xanax among others, is a short-acting benzodiazepine. It is most commonly used in short term management of anxiety disorders, specifically panic disorder or generalized anxiety disorder (GAD). Other uses include chemotherapy-induced nausea, together with other treatments. GAD improvement occurs generally.