A little about me: I’m 25, husband is 28. We’d been ttc for 11 months. I was diagnosed with PCOS in November. Started Femara and Metformin early December. This was my second iui/trigger/femara cycle, I did iui 24 hours after trigger (honestly I thought this was too early go figure). I’ve done previous cycles without iui and clomid and none were successful. Letrozole (Femara) is a drug prescribed for the treatment of certain postmenopausal women, or women who have been treated with tamoxifen. AHA News: After 4 Strokes, Rare Disease and Brain Surgery, Woman Helps Others Ancestry Matters When Seeking Matched Bone Marrow Donors Bad Info May Be Scaring Patients Away From Heart-Healthy Statins Do Doctors Hounded by Malpractice Claims Just Shift Their Practice Elsewhere? Anyway, I had a hysterectomy in February and am on a medication called Femara which prevents the testosterone which is manufactured in your adrenal glands from being turned into estrogen in your breasts (which normally happens even if your ovaries are removed). Anu Mar 25, 2018 06:29:41 AM ET. I'm on day 22 and mild cramps sometimes. Unusual feeling in lower stomach. Mild back ache. Very sleepy and tired mostly. Adjuvant Treatment. Anastrozole tablets are indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer. Letrozole is used to treat breast cancer in women. You may have it after other treatments, to reduce the risk of breast cancer coming back. Sometimes doctors give letrozole before surgery. Endometriosis and Infertility. Endometriosis can be associated with severe pain and fertility problems. About 30% to 40% of women with endometriosis have some trouble conceiving. Joanne, I am sorry to hear about your sleepless nights. Personally, I wouldn’t stop after only three pills. Please do not take anything you read here as medical advice.