As to causing short term memory loss, in long term use, to the best of my knowledge, that has not been a factor, as a side effect. Zoloft in general is a well tolerated drug. Whether it's occasional forgetfulness or loss of short-term memory that interferes with daily life, there are many causes of memory loss. Causes of Memory Loss We provide full service adult Short Term Memory Loss And Zoloft in a meticulously clean environment with state-of-the-art equipment. Dr. Sharp and his staff strive to provide consistently exceptional results whether your treatment requires implants, complicated bridgework, treatment for gum disease, dentures or simply routine restorations. For the last week and a half I have been experiencing what I consider to be a great deal of short term memory loss. Such as beginning a conversation and completely forgetting what my point was. The thought is totally gone as if I never had it to begin with. I also suffer from OCD, now Zoloft does cause memoroy loss I do not know if it is permanent, with regrds to amphetamines, I have never read anything about memory loss. Summary. Short-term memory loss is found among people who take Zoloft, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Xanax, and have Multiple sclerosis. Doctors give unbiased, trusted information on the benefits and side effects of Sertraline to treat Amnesia: Dr. Volicer on short term memory loss zoloft: Possible, can occur at higher dose, usually above 40mg. Per day. (Adapted from Improving Memory: Understanding age-related memory loss, a Harvard Medical School Special Health Report) Underactive thyroid. A faltering thyroid can affect memory (as well as disturb sleep and cause depression, both of which can be causes of forgetfulness). I have been taking Sertraline for 9 months.I do have noticed short term memory loss & prolong reaction time. I am thinking of stopping it to see if these side effects disappear or not. I am thinking of stopping it to see if these side effects disappear or not. Dear Tur, Your title was Zoloft, and I have been taking that drug for almost ten years. I have tried Lexapro and did not like it. The way Zoloft works for me is, I have to take it in the morning first thing, because I have nightmares if I take it in the evening.