Breast cancer in trans women is extremely rare, and while studies on cisgender women suggest that increasing E concentration may raise our risk, the overall risk is negligible (there have only been a handful of reported cases worldwide). Hormonal levels have been hypothesized to serve as proximal biological mechanisms underlying individual differences in risk taking. We conducted a systematic literature search and independent meta-analyses to assess the link between endogenous testosterone, estradiol, and cortisol levels and risk-taking related constructs (i.e., risk-taking. These conditions increase your risk of getting blood clots, especially if you are taking an estrogen product. You may need to stop this medication for a time or take special precautions. Estradiol may increase your risk of developing uterine cancer. Report any unusual vaginal bleeding right away. Using this medicine can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Using topical estradiol may increase your risk of developing ovarian cancer and gallbladder disease. You should talk to your doctor about these risks. In Summary. Commonly reported side effects of estradiol include: cerebrovascular accident, infection, malignant neoplasm of breast, endometrium disease, headache, and mastalgia. Estradiol is a paradoxical drug. Women who use it to reduce menopausal symptoms run an increased risk of cancer, but women who have recurrent breast cancer may be surprised when their doctors. Estrogen therapy decreased the risk of heart disease and mortality among women in their 50s but markedly increased these risks for women in their 70s. In contrast, the decreased breast cancer risk associated with estrogen use was seen regardless of age.