While Ranitidine is not approved for veterinary use by the FDA, it can be given to dogs by veterinarians for treatment. Although it is available over-the-counter, ranitidine should not be given to. Cimetidine, ranitidine, and famotidine are the commonly used H 2-receptor antagonists. Ranitidine is 3–13 times as potent on a molar basis as cimetidine in inhibiting gastric acid secretion. Famotidine is 20–150 times as potent as cimetidine. Use of Ranitidine Tablets in this age group is supported by adequate and well-controlled studies in adults, as well as additional pharmacokinetic data in pediatric patients and an analysis of the published literature (see CLINICAL PHARMACOLOGY: Pediatrics and DOSAGE AND ADMINSTRATION: Pediatric Use). Comments. No citations have been included in this BET as no publications were found looking at the use of ranitidine versus omeprazole in treating canine gastric ulceration (ie. no peer-reviewed evidence to answer the PICO question). Veterinarians often use ranitidine for dogs with mast cell tumors as these growths produce a large quantity of histamines. Ranitidine does not treat the tumor but lessons the side effects of the excessive histamines. Some vets also use ranitidine to combat the effects of torsion (stomach bloating) though it has not yet been established whether or not it is an effective course of treatment, in fact, some signs would suggest that it is actually detrimental to the condition overall. Stachura, J. et al. (1983) Comparison of the effect of omeprazole--a substituted benzimidazole--and ranitidine--a potent H2-receptor antagonist--on histamine-induced gastric acid secretion and the ultrastructure of canine parietal cells. Although the drug is officially only approved by the FDA for use in human beings, it can also be put to effect in canine systems as well. If your pet suffers from ulcers or is predisposed to stomach acidity issues, speak with your vet about the possibility of giving him treatment with ranitidine. British Small Animal Veterinary Association, Woodrow House, 1 Telford Way, Waterwells Business Park, Quedgeley, Gloucester, GL2 2AB, United Kingdom. Please consult your veterinarian before giving these or any other drug or herbal supplement to your pet while on Ranitidine. It is best to give these medications at least two hours prior or following the use of Ranitidine.