Buchman N(1), Strous RD, Baruch Y. Author information: (1)Beer Yaakov Mental Health Center, Sackler School of Medicine, Tel Aviv University, Beer Yaakov, Israel. Depressive disorders are frequently managed with long-term use of antidepressant medication. Even though the newer generation of selective As we've learned more about the long-term side effects, some of the top concerns that have emerged have to do with weight gain and diabetes. However, many other side effects can continue long term and can have a negative impact on your quality of life. Hackett and colleagues published their data in Developmental Cognitive Neuroscience in August 2017. They found Prozac had negative effects on attention span, impulsive behaviors and sleep in young monkeys. As of February 2018, the FDA had not added new warnings to Prozac’s label. An increased risk of suicidal thinking and behavior in children, adolescents, and young adults (aged 18 to 24 years) with major depressive disorder (MDD) and other psychiatric disorders has been reported with short-term use of antidepressant drugs. These important concerns are downplayed by Prozac's manufacturer, Eli Lilly and Co. Moreover, the published risks are based on short-term studies. Being on Prozac long term was not a good idea in my husband's situation and was likely creating a myriad of other health problems for him and for our family long term. It was as if the wires in.