Prednisone is a synthetic corticosteroid that reduces inflammation and suppresses the immune system. Prednisone is prescribed for a wide range of conditions, especially autoimmune diseases. Last night she had a minor nose bleed, I have heard of Prednisone doing damage to a dog if taken for an extended time and then stopped cold turkey,which our vet had us do. Reply. She hasn't had a nose bleed ever in her life. Could this be a side effect of the prednisone eye drops? She was one them for ~ 2 months. Longer that normal. Any clues? Could this be a side effect of the prednisone eye drops? I got nose bleeds allll the time! the only thing I could do was put vaseline in my nose. sounds gross but it kept it moist. deleted_user Prednisone (if taken for long periods of time) will make your capillaries (those are tiny blood vessels) weaker and give you a tendancy to bleed/bruise easier. How to Treat Nosebleeds in Dogs. Nosebleeds may seem fairly harmless, but in dogs, they usually indicate something else is wrong. Therefore, it's important to know what to do in the moment, such as keeping your dog still and applying an. Hi, I have German shepherd dog on prednisone, for DM-degenerative myleopathy, she has been on it for about 4-months. She takes a dose of 2-20 milg, tabs twice a day. Lately she has been experiencing She takes a dose of 2-20 milg, tabs twice a day. A spontaneous dog nose bleed may be an indication of a blood-clotting disorder, such as hemophilia or von Willebrand’s disease. Tick-borne infections such as canine ehrlichiosis and Rocky Mountain Spotted Fever can also cause nose bleeding in dogs. A bleeding nose can come from several sources. It may be the result of a condition called coagulopathy — a condition where the blood is not coagulating as it should. It may be the result of a condition called coagulopathy — a condition where the blood is not coagulating as it should. To stop a dog's nose bleed, the dog must be kept as calm and still as possible. The more the dog will move and be anxious, the less likely the nose bleed to stop due to the increased blood pressure associated with anxiety and stress. If your dog suddenly begins to bleed from the nose, remain calm. It is of equal importance to keep your pet quiet and relaxed in order to prevent the nose from bleeding more intensely.