Percocet® and Xartemis™ are available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program. Before using Percocet. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will. Percocet (acetaminophen and oxycodone) is used to relieve moderate to severe pain. Includes Percocet side effects, interactions and indications. Percocet or oxycodone and acetaminophen is a prescription drug used to treat moderate to severe pain. Side effects of may include constipation, drowsiness, nausea, and vomiting. Warnings, drug interactions, dosage, and pregnancy and breastfeeding safety information are provided. Other brand names for oxycodone and acetaminophen include Roxicet, Tylox, Endocet. Percocet is a painkiller, part of a family drugs known as opioids. Percocet is the brand name of a drug that mixes oxycodone and acetaminophen. Is Percocet helpful for Swollen Hands? can Percocet cause Swollen Hands? Percocet is mentioned in 10 posts about Swollen Hands. Percocet may cause sedation which may impair your reaction skills and affect your ability to drive or operate machinery. Do not drive or operate machinery if Percocet impairs you in this way. Withdrawal symptoms (muscle and bone pain, diarrhea, insomnia, vomiting) may occur if long-term Percocet is stopped abruptly. Your doctor will advise you.