Nitroglycerin is having headache as major side effect. It causes cerebral vasodilation and this causes headache. Painkiller drugs are the mainstay of treatment for nitro induced headache. The Nitroglycerin gives you a bit of a headache, but it is better than the alternative. I also take Colace daily and stay on a high fiber diet and drink a LOT of water. I hope this helps a little - I didn't realize so many others are suffering from similar issues. All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. However, during long-term nitrate treatment, a headache often abates over a period of time, whilst the anti-anginal effect remains, implying tolerance in the cephalic more than in coronary arteries. Organic nitrates induce headache via release of nitric oxide, a potent regulator of vascular tone [ 3 ]. Doctors give unbiased, trusted information on whether Deponit can cause or treat Headache: Dr. Ali on nitroglycerin headache treatment: I have seen weather related migraine headaches respond to b2 as well as high dose injectable b12, and magnesium. Additionally, especially when starting nitroglycerin, it might be useful to take a little bit of over the counter pain killers such as acetaminophen the first few days; and typically after a few. The purpose of the present study was to clarify the possible relationship between nitroglycerin (NTG)-induced headache and both vascular functional and organic atherosclerosis. Nitroglycerin is used to treat or prevent attacks of chest pain. Nitroglycerin may also be used for purposes not listed in this medication guide. nitroglycerin headache، Sublingual nitroglycerin tablets are used to treat episodes of angina (chest pain) in people with coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Nitroglycerin stops the angina attacks, but gives him a severe headache. He doesn't want to be dependent on this med, but would obviously prefer not to have the pain at all. He is also fearful with each bout of what may happen next. My father is willing to travel to your clinic if there is any hope for an improvement in his quality of life.