Study selection. We included randomized controlled trials in which nifedipine was used for tocolysis in patients with preterm labor compared with alternative tocolytic agents, placebo or no treatment. Tocolysis is the use of medication to prevent preterm delivery. Preterm labor is defined as regular uterine contractions causing cervical dilation. Several classes of medications are used for. for preterm birth interventions is welcome. With regard to the place of tocolysis, the guidelines present a balanced view of the current uncertainties and indicate a preference for nifedipine as the drug of choice when tocolysis is considered, while emphasising the need for further research. The short-term effect of nifedipine tocolysis on placental, fetal cerebral and atrioventricular Doppler waveforms. Ultrasound Obstet Gynecol 2004; 24:761. Ultrasound Obstet Gynecol 2004; 24:761. Mari G, Kirshon B, Moise KJ Jr, et al. Doppler assessment of the fetal and uteroplacental circulation during nifedipine therapy for preterm labor. Study Design. Pregnant women receiving oral nifedipine underwent steady-state pharmacokinetic testing over one dosing interval. DNA was obtained and genotyped for cytochrome P450 (CYP) 3A5, and CYP3A4*1B. Detailed Nifedipine dosage information for adults. Includes dosages for Hypertension, Angina Pectoris and Angina Pectoris Prophylaxis; plus renal, liver and dialysis adjustments. CLINICAL PRACTICE GUIDELINE TOCOLYTIC TREATMENT IN PREGNANCY 3 Key Recommendations 1. Antenatal corticosteroids significantly reduce the incidence and severity 1 PROTOCOL: Tocolysis with Nifedipine Background: Nifedipine (Adalat) is a calcium-channel blocker that acts by relaxing smooth muscle. Its main use until now has been in the management of hypertension and angina. Individualized Dosing of Nifedipine For Tocolysis in Preterm Labor The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.