Aleve (naproxen) works well for treating mild to moderate pain or inflammation, and lasts longer than other NSAIDs. Ecotrin (aspirin) can be used for pain and fever relief or heart protection, and is generally very safe and affordable. No, naproxin and aspirin are not the same. I know this because I used to be the IT manager at a plywood mill up in Northern Ontario. Very close to the US border. Naproxen and aspirin are both widely available medications that are used to control mild to moderate pain. Individuals sometimes combine these medications in an effort to receive more pain relief. Uses. See also Warning section. Naproxen is used to relieve pain from various conditions such as headache, muscle aches, tendonitis, dental pain, and menstrual cramps. Naproxen and aspirin are two different drugs, so it is technically correct that naproxen *does not* contain aspirin. However, they are related drugs, and if you are allergic to one of them, you *might* be allergic to the other. Naproxen's medical uses are related to its mechanism of action as an anti-inflammatory compound. Naproxen is used to treat a variety of inflammatory conditions and symptoms that are due to excessive inflammation , such as pain and fever (naproxen has fever-reducing, or antipyretic , properties in addition to its anti-inflammatory activity). Naproxen sodium is not recommended for children under 2. Ibuprofen is considered safe for children 6 months and older in the right dose. Ibuprofen is considered safe for children 6 months and. Avoid taking aspirin while you are taking naproxen. Ask your doctor before taking any other medication for pain, arthritis, fever, or swelling. Many medicines available over the counter contain aspirin, salicylates, or other medicines similar to naproxen (such as ibuprofen or ketoprofen). Aspirin. Most patients benefit from aspirin and other NSAIDs with few side effects. However, serious side effects can occur and generally tend to be dose-related. Before taking naproxen, tell your doctor and pharmacist if you are allergic to naproxen, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and ketoprofen, any medications for pain or fever, other medications, or any of the ingredients in naproxen products.