the tylenol quick release with the little holes in the side. While a clear risk has not been established, women who are trying to conceive may wish to avoid ibuprofen. When ibuprofen is used as directed in the first and second trimester of pregnancy, it is not associated with an increased risk for birth defects. As far as I know, Tylenol is safe while TTC. I have even heard of doctors saying it's OK while pregnant. I feel your pain in that I get pretty bad headaches with the Femara too. Taking Ibuprofen while TTC: Hi Ladies, So I have been struck with a terrible head cold and without even thinking about it have taken large amounts of Nurofen and sudafed over the past five days or so, it then occured to me that I should check whether Ibuprofen is safe to take while TTC.. turns out its not, I'm due to ovulate today and had my. I was researching this myself and found one article that claimed a lot of unexplained infertility stems from women taking NSAID meds while ttc. I'm sticking to baby aspirin and half-doses of Tylenol. 8 citymouse , Jul 12, 2011 I try not to take anything while ttc, but if I have to, I only take a regular strength tylenol. Ibuprofen and TTC - BabyandBump I take quite a lot (800 milligrams 2x a day) of ibuprofen for joint pain and I have read that it can prohibit the fertilized egg from attaching in the uterus.sounds. HI I have been TTC this month, so i really don't know yet, i've done 2 tests but it's too early to tell because my period is only due in 9-10. I had dental work started on Weds, after my almost 1 year old head butted me a bit too hard last weekend lol, and the follow up appointment isn't until next Thurs. Just an FYI - When I was talking to the nurse at the RE yesterday, she told me not to take ibuprofen (Advil, Motrin, etc) while TTC, becasue it can cause you not to O and will interfere with implantation! Here's more. Can Ibuprofen Interfere with Ovulation?Posted Apr 23 2009 5:28pm Yes! Ibuprofen and other drugs that belong to non steroidal anti inflammatory drug class like aspirin, excedrin, motrin, advil, aleve etc. can interfere with ovulation.