Zafirlukast Versus Montelukast. One author (R.E.) discovered that montelukast (Singulair; Merck & Co, West Point, PA), a pharmaco-logic agent similar to zafirlukast but requiring only a single dose at bedtime, also reduced the incidence of capsular contracture. Moved Permanently. The document has moved here. But as capsular contracture is one of the biggest problems with implants, I throw the kitchen sink at trying to avoid it. And singulair is included in this. And singulair is included in this. This blog is in reference to a study out of UCLA. Effects of Singulair (Montelukast) Treatment for Capsular Contracture Article in Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery 30(3):404-8 · July 2010 with 2,769. Statement of Significance. Capsular contracture is troublesome, making the tissues hardened around the silicone implant. This causes serious pain and discomfort to the patients, often leading to secondary surgery for implant replacement. The major study that showed the efficacy of Sigulair for Capsular contracture was dosed at 10mg a day for 3 months. My personal experience shows that this is effective at least 50% of the time. The treatment of capsular contracture with leukotriene inhibitors (including Singulair and Accolate [zafirlukast]) has been reported in the medical literature. Anecdotal reports have shown that. What causes capsular contracture? Historically, the cause of the chronic inflammation that, in turn, stimulates capsular contracture was free silicone oils from early model silicone gel implants. In those days, capsular contracture risk was all but certain, and usually severe. Capsular contracture – or abnormal firmness of the breasts due to a scar tissue build-up around the breast implant – is arguably the 1 unsolved problem of breast implant surgery. It’s unpredictable and very frustrating for surgeon and patient. One of the biggest difficulties in dealing with capsular contracture is that we are not sure what causes the normally thin and pliable capsule (which forms around each and every breast implant) to thicken and contract. We have a leading theory, but, as of yet, no magic bullet to universally prevent it.