Nyquil, Tylenol, Ibuprofen, Aleve, and other meds should not be mixed with booze. Some might think that the mixture is safe enough, but the results can be dangerous. often find that the medication stops working. So I was thinking I could take Aleve since it lasts up to 12 hours and then take a Vicodin again when I can. Just wanting to be able to sleep all night without all this pain. Just wanting to be able to sleep all night without all this pain. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Jacobson on vicodin and aleve: These two medications can be taken together and are often used in combination for acute pain. Best Answer: Yes, way too much acetomenaphin going on here. If the vicodin isn't working on it's own try an NSAID with it like Iburpofen or Naprosyn, it's a different type of pain reliever and is ok to take with vicodin which already has acetomenaphin. When you are taking any kind of drug combination, please do not rely on hear-say. Check with your doctor or pharmacist. Mixing drugs that are not compatible is very dangerous. Mixing Tylenol and Aleve causes a rapid and more pronounced drop in platelet production, and can be lethal. Patients should be monitored for blood loss and have regular check-ups with a doctor. Patients should be monitored for blood loss and have regular check-ups with a doctor. If it's hydrocodone/APAP (the APAP stands for acetaminophen, or Tylenol) then you have no problem taking it with Aleve. Don't take it if it's a mixture of hydrocodone with either aspirin or ibuprofen though. Naproxen and acetaminophen both treat mild to moderate pain, but they work differently. Learn if you can take them together and how to use them safely. My wife has been advised by her OB-GYN that you should not take Aleve while pregnant. It has been linked to kidney development problems in the fetus and possibly miscarriages.