Skin Reactions (Dry Skin, Flushing, Hyperpigmentation, Nail Changes, Photosensitivity, Radiation Recall) chemotherapy side effects, causes, symptom management and when to contact your healthcare provider during cancer treatment. The supportive therapies (e.g. antiemetics, premedications, etc.), infusion times, diluents, volumes and routes of administration, if included, are listed as defaults. Methotrexate is contraindicated in pregnancy in women who are being treated for nonmalignant diseases (e.g., psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis). Preservation of Fertility and Pregnancy during chemotherapy, side effects, causes, symptom management and when to contact your healthcare provider during cancer treatment. Methotrexate is contraindicated in pregnancy in women who are being treated for nonmalignant diseases (e.g., psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis). Ejima-Yamada K, Oshiro Y, Okamura S, et al. Epstein-Barr virus infection and gene promoter hypermethylation in rheumatoid arthritis patients with methotrexate-associated B cell lymphoproliferative disorders. Learn about the potential side effects of etoposide. Includes common and rare side effects information for consumers and healthcare professionals. Methotrexate reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). The supportive therapies (e.g. antiemetics, premedications, etc.), infusion times, diluents, volumes and routes of administration, if included, are listed as defaults. Methotrexate is an antimetabolite of the antifolate type. It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis.