Standard therapy to prevent recurrent venous thromboembolism includes 3 to 12 months of treatment with full-dose warfarin with a target international normalized ratio (INR) between 2.0 and 3.0. Conventional-intensity warfarin therapy is more effective than low-intensity warfarin therapy for the long-term prevention of recurrent venous thromboembolism. The low-intensity warfarin regimen. Ridker PM, Goldhaber SZ, Danielson E, Rosenberg Y, Eby CS, Deitcher SR, for the Prevention of Recurrent Venous Thromboembolism (PREVENT) Investigators. Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. To be published in N Engl J Med 2003; 348(15 warfarin therapy for the long-term prevention of recurrent venous thromboembolism. The The low-intensity warfarin regimen does not reduce the risk of clinically important bleeding. 1. N Engl J Med. 2003 Aug 14;349(7):631-9. Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. Comparison of Low-Intensity Warfarin Therapy With Conventional-Intensity Warfarin Therapy for Long-Term Prevention of Recurrent Venous Thromboembolism The Prevention of Recurrent Venous Thromboembolism (PREVENT) trial was initiated in July 1998 to test the hypothesis that long-term, low-intensity warfarin therapy (target INR, 1.5 to 2.0) might. Introduction. Paul M. Ridker, MD and colleagues recently published, Long-Term, Low-Intensity Warfarin Therapy for the Prevention of Recurrent Venous Thromboembolism (PREVENT), a randomized. Deitcher SR, for the Prevention of Recurrent Venous Thromboem-bolism (PREVENT) Investigators. Long-term, low-intensity warfarin therapy for the prevention of recur-rent venous thromboembolism. To be published in N Engl J Med2003; 348(15). Background:Current guidelines rec-ommend that full-dose warfarin be continued for 6–12 months after an id-iopathic episode of venous throm-boembolism (VTE. 63 Kearon C, Ginsberg JS, Kovacs MJ, et al. Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl J Med.