The octanol/water partition coefficient is not the same as the ratio of a chemical's solubility in octanol to its solubility in water, because the organic and aqueous phases of the binary octanol/water system are not pure octanol and pure water. Atenolol is a beta blocker medication primarily used to treat high blood pressure and heart-associated chest pain. Other uses include the prevention of migraines and treatment of certain irregular heart beats. L'atenolol est un beta-bloqueur indiqué comme antihypertenseur, antiarrhythmique (classe II). Données physico-chimiques : Nombre CAS : 29122-68-7 The measured n-octanol/water partition coefficients (log P ow) were compared with those reported in the literature. The comparison indicated that the measured partition coefficients have very good agreement with literature data. Atenolol is a synthetic isopropylamino-propanol derivative used as an antihypertensive, hypotensive and antiarrhythmic Atenolol acts as a peripheral, cardioselective beta blocker specific for beta-1 adrenergic receptors, without intrinsic sympathomimetic effects. Literature References: Cardioselective b-adrenergic blocker. Prepn: Barrett et al., DE 2007751; eidem, US 3663607 and US 3836671 (1970, 1972, 1974 all to I.C.I.). Detailed Atenolol dosage information for adults and the elderly. Includes dosages for Hypertension, Myocardial Infarction, Angina Pectoris and more; plus renal, liver and dialysis adjustments. log P = + 1.18 log D = - 2.44 N O OH OH F F Glucuronic acid resorbtion metabolism intestine Here is how ! enterohepatic cyle. RSA 2008-2009 26 But is the molecule stable ? N O OH OH F F is this not a β-lactam ? RSA 2008-2009 27 β-lactams are unstable because of anchimeric assistance … N O COOH Carbapenem greater intrinsic activity due to larger instability of the β-lactamringbecause of C1. ratings for log POW 5 for data determined by the slow-stirring method, exclusively. In more than 15 years of application of this technique adequate protocols have been developed for P OW determination using the slow-stirring method. Atenolol is a water-soluble, ionizable drug and suffers from poor bioavailability when given by oral route due to its incomplete intestinal absorption and first-pass metabolism. Being a BCS class III drug, Atenolol has low log P (0.23) value, which also may be the reason for its poor intestinal absorption. Iontophoretic delivery using Ag/AgCl electrodes with current density of 0.35 mA/cm(2.