In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life. Calculation of loading dose and maintenance dose to produce target plasma concentrations in individuals. dose [dōs] the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation. absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads. air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens. booster dose an. De très nombreux exemples de phrases traduites contenant a loading dose – Dictionnaire français-anglais et moteur de recherche de traductions françaises. Medical definition of loading dose: a large initial dose of a substance or series of such doses given to rapidly achieve a therapeutic concentration in the body. Übersetzung im Kontext von „loading dose“ in Englisch-Deutsch von Reverso Context: Patients need to receive a loading dose on the first day of treatment.