Addiction is often used interchangeably with terms such as dependence and substance use disorder (see further on in definitions). Addiction is generally defined as a primary, chronic, neurobiologic disease, with genetic, psychosocial, and environmental factors influencing its development and manifestations. a aa aaa aaaa aaacn aaah aaai aaas aab aabb aac aacc aace aachen aacom aacs aacsb aad aadvantage aae aaf aafp aag aah aai aaj aal aalborg aalib aaliyah aall aalto aam.