The National Institutes of Health recommends Lactobacillus acidophilus, which can be taken orally or it can be used as a vaginal suppository. Vaginal suppositories seem to be most effective when used twice daily for one week. Suppositories should contain between 100 million and 1 billion live cells. Acidophilus is a bacteria that exists naturally in the body, primarily in the intestines and the vagina. Acidophilus helps maintain an acidic environment in the body, which can prevent the growth of harmful bacteria. Compare Acidophilus vs. Diflucan, which is better for uses like: Yeast Infection and Thrush. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Acidophilus 4.8/5 over Diflucan 3.1/5 in overall satisfaction. Acidophilus (Lactobacillus acidophilus), a bacterium found in the mouth, intestine and vagina, is used as a probiotic. Probiotics are good bacteria that are either the same as or very similar to the bacteria that are already in your body. Can I take Diflucan with lactobacillus acidophilus? There is no known interaction between Diflucan and lactobacillus acidophilus in our records. However, an interaction may still exist. Acidophilus (Lactobacillus acidophilus) is called the 'gut-friendly' bacteria. The name translates to 'acid-loving milk-bacterium'. It helps in the production of vitamin K and lactase in the body, and also helps strengthen the immune system. Lactobacillus acidophilus is also possibly effective in treating irritable bowel syndrome, bacterial vaginal infection, colic in babies, lung infections in children, skin problems in children who are allergic to milk, and other conditions. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Jayaraj on should i take probiotics with diflucan: Can take both together. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Jayaraj on should i take probiotics with diflucan: Can take both together. Acidophilus, known scientifically as Lactobacillus acidophilus, is a species of good or friendly bacteria found primarily in the small intestine. probiotic consisting of two Lactobacillus species (a Lactobacillus rhamnosus and a Lactobacillus reuteri ) significantly improved the effectiveness of an anti-fungal.