The capacity of Labetalol to block alpha receptors in man has been demonstrated by attenuation of the pressor effect of phenylephrine and by a significant reduction of the pressor response caused by immersing the hand in ice-cold water (“cold-pressor test”). TRANDATE- labetalol hydrochloride tablet Prometheus Laboratories Inc.-----TRANDATE (labetalol hydrochloride) Tablets DESCRIPTION TRANDATE Tablets are adrenergic receptor blocking agents that have both selective alpha- Phenylephrine (Neosynephrine) raises BP, lowers HR, and may decrease CO In spinal cord injuries, avoid phenylephrine (use dopamine first-line, even before fluids) Nitroprusside should be avoided as it has been shown to raise ICP in patients with intracranial mass lesions [J Neurosurgery 48: 329, 1978]. Topical phenylephrine solutions are widely used in eye procedures to promote pupil dilation without cycloplegia. We report a case of intraoperative severe hypertension and acute pulmonary edema occurring in a child during retinal surgery after possible systemic absorption of topical phenylephrine eyedrops. Labetalol is a medication used to treat high blood pressure and in long term management of angina. This includes essential hypertension, hypertensive emergencies, and hypertension of pregnancy. In essential hypertension it is generally less preferred than a number of other blood pressure medications. It can. for labetalol hydrochloride The use of labetalol in maternal hypertension is not known to be harmful, except possibly in the first trimester. If labetalol is used close to delivery, infants should be monitored for signs of alpha-blockade (as well as beta blockade). Phenylephrine is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to relieve hemorrhoids. [1] [2] While marketed as a decongestant, taken by mouth at recommended doses it is of unclear benefit for hay fever. [1] Pharmacodynamics. The capacity of labetalol to block alpha-receptors in man has been demonstrated by attenuation of the pressor effect of phenylephrine and by a significant reduction of the pressor response caused by immersing the hand in ice-cold water ( cold-pressor test ). Find patient medical information for Labetalol Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. NDA 19425/S-021 Page 4 Trandate ® (labetalol hydrochloride) Injection DESCRIPTION: Trandate Injection is an adrenergic receptor blocking agent that has both selective alpha1­.