Find patient medical information for Zofran Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Learn which medicines are safe to take for nausea during pregnancy if home remedies don't work. A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea, vomiting and in some cases, hyperemesis gravidarum, in early pregnancy) poses no risk to the developing fetus. For many women, the first weeks of pregnancy are marked by morning The anti-nausea drug Zofran is approved for the prevention of nausea and vomiting caused by cancer chemotherapy, radiation and surgery. Doctors also prescribe the medication to treat morning sickness, though studies offer conflicting results about its potential for causing birth defects. Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Ondansetron, a potent antiemetic agent, is a 5-hydroxytryptamine receptor 3 antagonist that blocks the effects of serotonin. It was designed originally for chemotherapy-induced nausea and vomiting. Ondansetron comes as a tablet, a rapidly disintegrating (dissolving) tablet, and an oral solution (liquid) to take by mouth. The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. It is used to treat or prevent upset stomach and throwing up. What do I need to tell my doctor BEFORE I take Zofran? If you have an allergy to ondansetron or any other part of Zofran (ondansetron injection). Pictures of Zofran (Ondansetron Hydrochloride Tablets and Solution), drug imprint information, side effects for the patient. Zofran (Ondansetron) is used for treating or preventing nausea and vomiting caused by cancer treatments such as chemotherapy and radiation therapy.