Aleve (naproxen) is good for relieving pain from common conditions like menstrual cramps, toothaches, and arthritis. It lasts longer than other NSAIDS so you don't have to take it as often. So now I take 7.5mg of Percocet 3x's daily, Soma 350mg 3x's daily (with the Perc's), and I take 500mg Naproxen 2x's daily and I'm still in pain. My Dr wants me off the Perc's and Soma but I'm afraid of the pain I'll be in. There is no drug interaction between these two medications, so the answer is yes, it is safe to take Percocet and Aleve at the same time. They don’t have the same mechanisms of action that benefit alleviation of pain. Individuals are cautioned to take Naproxen with a full glass of water or with sustenance to decrease the shot of having a bothered stomach. Brought these lines nevertheless, the arrangement may set aside greater opportunity to work. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Keller on oxycodone and naproxen: These two medications can be taken together and are often used in combination for acute pain. Naproxen and acetaminophen both treat mild to moderate pain, but they work differently. Learn if you can take them together and how to use them safely. Hi AE, Hope you have found an answer to your question. I just want to add one thing: On this site, if you list your current drugs under your profile, the site will tell you about any and all drug interactions, some of which are minor, others deserve your immediate attention. Actually Thor, you can take naproxen with acetaminophen but you dont want to take it with another NSAID like ibuprofen, ketoprofen, celebrex, aspirin etc. Actaminophen is not an NSAID, it is in a different class. Best Answer: yes different meds. percocet is oxycodone with acetominophen. aleve is naproxen. all three are unrelated and you can take them all together. Can patients take Hydrocodone and Naproxen or Aleve together From a pharmacology standpoint, there is no harm if Naproxen or Aleve is taken together with Hydrocodone. So if hydrocodone isn’t controlling the pain well, patients can use Naproxen or Aleve and Hydrocodone but only with physician instructions.