Ibuprofen is known to interact with many different drugs. It's always important to share with your doctor and pharmacist all prescription, non-prescription, illegal, recreational, herbal. About Fever: Normal body temperature varies between people. Even in the same person, normal body temperature varies depending on age, activity, and time of day. Chronic use of ibuprofen can result in gastritis, ulceration with or without GI perforation, and/or GI bleeding, which can occur at any time, often without preceding symptoms. Learn about Motrin (Ibuprofen) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Aspirin is medication used to treat fever, pain, and inflammation in the body. It also prevents blood clots, stroke, chest pain, and heart attack in certain people. Learn about Vicoprofen (Hydrocodone and Ibuprofen) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Aspirin is used by many people at risk to help prevent heart attacks and stroke, but ibuprofen may interfere with its heart-protection properties. Ibuprofen is used primarily to treat fever (including post-vaccination fever), mild to moderate pain (including pain relief after surgery), painful menstruation, osteoarthritis, dental pain, headaches, and pain from kidney stones. Drug Interactions. Ibuprofen should not be mixed with aminoglycosides such as Paromycin, Garamycin or Tobi. Aspirin should not be mixed with NSAIDs (like naproxen), anti-depressants like Celexa and Lexapro, or alcohol because it increases the risk of gastrointestinal bleeding. Find patient medical information for Bayer Aspirin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.