Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). It is commonly used to treat blood clots such as deep vein thrombosis and pulmonary embolism and to prevent stroke in people who have atrial fibrillation, valvular heart disease or artificial heart valves. Less commonly. Coumadin Interaction with herbs, vitamins, enzymes, food, diet restrictions and natural supplements, risks, and side effects November 20 2016 by Ray Sahelian, M.D. In both cases I placed a subclavian central line without difficulty, bleeding or complication. I don't think one will ever find a randomized trial comparing the complication rate of placing a subclavian line in folks on anticoagulation with therapeutic or even elevated INR compared with patients not on anticoagulation. Individualized Dosing. The dosage and administration of COUMADIN must be individualized for each patient according to the patient’s International Normalized Ratio INR response to the drug. Family Medicine Centre. The Ottawa Hospital – Family Health Team. Appendix A. Warfarin (Coumadin®) maintenance dosing algorithm. INR up to 4.9: Managed by nurse Treatment with warfarin should be started on the same day as heparin, low molecular weight heparin (LMWH), or fondaparinux and continue for 5 days or more and until the INR is 2 or more for 24 hours or more. Coumadin ® is indicated for: • Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism (PE). • Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation (AF) and/or cardiac valve replacement. I don't understand Warfrin. If the INR is. lets say 1.2 and your on 2mg of Coumadin the Dr will increase it to. let say 5mg. I thought the lower the number, the thinner the blood. WHAT IS WARFARIN? Warfarin (brand names: Coumadin, Jantoven) is a prescription medication that interferes with normal blood clotting (coagulation). WARNING. BLEEDING RISK. COUMADIN can cause major or fatal bleeding [see WARNINGS AND PRECAUTIONS]. Perform regular monitoring of INR in all treated patients [see DOSAGE AND ADMINISTRATION].