Many With Migraines Given Narcotics, Barbiturates. These are a poor choice, especially for children, doctors say. From the WebMD Archives. By Amy Norton. HealthDay Reporter. WEDNESDAY, June 17. Take the Imitrex first, at the onset of the headache. Once you have the migraine under control, you can take your sedative if you need to. Once you have the migraine under control, you can take. Those include drugs such as sumatriptan (Imitrex, generics) and rizatriptan (Maxalt, generics). People with more severe or more frequent migraine attacks may need preventive medications. Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches. It is taken by mouth, in the nose, or by injection under the skin. Effects generally occur within three hours. You can easily overdose with methadone because it mask the effects of other opiates so you think I can't even feel that, which leads you to take more and more until its too late. Never mix. Migraine sufferers may unknowingly be making their painful headaches worse if they use drugs like OxyContin and Percocet, popular opiate painkillers that carry a high potential for abuse and addiction. Summary. Drug interactions are reported among people who take Imitrex and Suboxone together. This study is created by eHealthMe based on reports of 45 people who take Imitrex and Suboxone from FDA, and is updated regularly. There are many treatment options available for migraines (mainly the triptans - sumatriptan, eletriptan, frovatriptan, etc) that aren't drugs of abuse and are extremely effective (much more effective than opiates in my experience). Does Imitrex contain Methadone? Can I take Imitrex together with Methadone? 65 Discussions on Imitrex and Methadone on Treato - Page 2.