I was taking 400mg 4x a day for years until it ate my stomach out. I now take Naproxen 500mg 2x a day. 2 a day just do not last, can Ibuprofen be take inbetween the 2 Naproxen. Tantboom; There really is not a huge difference one seems to work better than the other for some people but you never take them together they are in the same family of drug. The main ingredient in aspirin, salicin, is the oldest pain reliever in history, but it took time and science before it became the drug we recognize today. Blood tests will be needed while you take indomethacin to monitor your kidney and liver functions. If you have kidney or liver problems, you may need to take a lower dose. Of course, no medication is a miracle cure all. While ibuprofen and naproxen are two of the most commonly available NSAIDs available and hold a low rate of direct causes of death and hospitalization, there are still risks and issues with using them. Ibuprofen (Advil, Motrin) and meloxicam (Mobic) belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include indomethacin , nabumetone (Relafen), and several others. When you have pain from such ailments as the common headache, the last thing you want to do is an in-depth study of ibuprofen vs. naproxen to decide which is best to take. Drug Interactions. Ibuprofen should not be mixed with aminoglycosides such as Paromycin, Garamycin or Tobi. Aspirin should not be mixed with NSAIDs (like naproxen), anti-depressants like Celexa and Lexapro, or alcohol because it increases the risk of gastrointestinal bleeding. Naproxen (Aleve) and ibuprofen (Advil, Motrin) are two of the most popular medication choices for muscle aches, joint pain, and inflammation from conditions like osteoarthritis. The most common side effects from ibuprofen are: rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, and.