Two pop into my head: first-generation antihistamines, like diphenhydramine and doxylamine, or benzodiazepines. Benzodiazepines (a low dose to respiratory depression of course) I hear can potentiate opiates, in this case, let's say 35 mg of hydrocodone. Opiate/Opiod Potentiating Guide I have always been a fan of potentiating his opiates, and now looking through this forum, he did not find one solid thread that explains how potentation works and how to do it, etc. Diphenhydramine failed to potentiate the analgesic effect of such endogenous opioid activity. The potentiating effect of antihistamines may therefore be mediated by mechanisms whose influence is restricted to systemically administered opiates. I felt it to slightly potentiate my high earlier, but with only a 25mg Benadryl. 15mg Hydrocodone with a 25mg Benedryl tablet worked fairly well for me. How much diphenhydramine did you take at the time? DATE: 26.06.2012 AUTHOR: guigyptia benadryl potentiate opiates Does hydroxyzine pamoate potentiate opiates? - Yahoo! Answers Using Antihistamines, Anticholinergics, and Depressants To Potentiate Opiates. with moderate to strong anticholinergic action like diphenhydramine (Benadryl. I felt it to slightly potentiate my high earlier, but with only a 25mg Benadryl. 15mg Hydrocodone with a 25mg Benedryl tablet worked fairly well for me. (opioids) The Ultimate Opiate Potentiation Thread [Archive You can include boosting opiates/opioids with more or other opioids; or other us viagra For codeine diphenhydramine is about the only thing that has Diphenhydramine potentiates narcotic but not endogenous opioid Diphenhydramine potentiates narcotic but not endogenous opioid analgesia. Benadryl(diphenhydramine HCl) and CPM(chlorpheniramine maleate) are both over-the-counter anti-histamines that increase the analgesic and euphoric properties of opiates to some extent. They also help cut down on the ope-itch. In addition, these guys also slightly inhibit subset CYP2D6. If you, or a loved one, are abusing opiates, with or without potentiators, immediate intervention and treatment are essential. It is possible to manage the cycle of dependence and addiction, and get on the road to living a healthier, drug-free life. CLICK HERE TO FIND OUT MORE. There are literally dozens of chemicals that can potentiate opiates, many with similar mechanisms. We will start with the most well-known ones slowly move into the more novel ones as we go down the list.